The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more insight into the mechanism underlying these deletions, we have studied the occurrence and nature of abnormalities in one of these genes, the B-cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T., van Reijmersdal, Simon V., van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M., Geurts van Kessel, Ad, van Leeuwen, Frank N., Kuiper, Roland P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280973/
https://www.ncbi.nlm.nih.gov/pubmed/22359517
http://dx.doi.org/10.1371/journal.pgen.1002533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280973/
https://www.ncbi.nlm.nih.gov/pubmed/22359517
http://dx.doi.org/10.1371/journal.pgen.1002533

Ejemplares similares