Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied prokaryotes, encode two ClpP homologs, ClpP1 and ClpP2, in a si...

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Detalles Bibliográficos
Autores principales: Raju, Ravikiran M., Unnikrishnan, Meera, Rubin, Daniel H. F., Krishnamoorthy, Vidhya, Kandror, Olga, Akopian, Tatos N., Goldberg, Alfred L., Rubin, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280978/
https://www.ncbi.nlm.nih.gov/pubmed/22359499
http://dx.doi.org/10.1371/journal.ppat.1002511

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