Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers

We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV nega...

Descripción completa

Detalles Bibliográficos
Autores principales: Pottiez, Gwenael, Jagadish, Teena, Yu, Fang, Letendre, Scott, Ellis, Ronald, Duarte, Nichole A., Grant, Igor, Gendelman, Howard E., Fox, Howard S., Ciborowski, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281056/
https://www.ncbi.nlm.nih.gov/pubmed/22359561
http://dx.doi.org/10.1371/journal.pone.0031031
Descripción
Sumario:We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.

Ejemplares similares