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Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers
We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV nega...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281056/ https://www.ncbi.nlm.nih.gov/pubmed/22359561 http://dx.doi.org/10.1371/journal.pone.0031031 |
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author | Pottiez, Gwenael Jagadish, Teena Yu, Fang Letendre, Scott Ellis, Ronald Duarte, Nichole A. Grant, Igor Gendelman, Howard E. Fox, Howard S. Ciborowski, Pawel |
author_facet | Pottiez, Gwenael Jagadish, Teena Yu, Fang Letendre, Scott Ellis, Ronald Duarte, Nichole A. Grant, Igor Gendelman, Howard E. Fox, Howard S. Ciborowski, Pawel |
author_sort | Pottiez, Gwenael |
collection | PubMed |
description | We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins. |
format | Online Article Text |
id | pubmed-3281056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32810562012-02-22 Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers Pottiez, Gwenael Jagadish, Teena Yu, Fang Letendre, Scott Ellis, Ronald Duarte, Nichole A. Grant, Igor Gendelman, Howard E. Fox, Howard S. Ciborowski, Pawel PLoS One Research Article We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins. Public Library of Science 2012-02-16 /pmc/articles/PMC3281056/ /pubmed/22359561 http://dx.doi.org/10.1371/journal.pone.0031031 Text en Pottiez et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Pottiez, Gwenael Jagadish, Teena Yu, Fang Letendre, Scott Ellis, Ronald Duarte, Nichole A. Grant, Igor Gendelman, Howard E. Fox, Howard S. Ciborowski, Pawel Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers |
title | Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers |
title_full | Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers |
title_fullStr | Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers |
title_full_unstemmed | Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers |
title_short | Plasma Proteomic Profiling in HIV-1 Infected Methamphetamine Abusers |
title_sort | plasma proteomic profiling in hiv-1 infected methamphetamine abusers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281056/ https://www.ncbi.nlm.nih.gov/pubmed/22359561 http://dx.doi.org/10.1371/journal.pone.0031031 |
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