The Orphan Nuclear Receptor LRH-1 and ERα Activate GREB1 Expression to Induce Breast Cancer Cell Proliferation

BACKGROUND: Liver Receptor Homolog 1 (LRH-1, NR5A2) is an orphan nuclear receptor that is over-expressed in cancers in tissues such as the breast, colon and pancreas. LRH-1 plays important roles in embryonic development, steroidogenesis and cholesterol homeostasis. In tumor cells, LRH-1 induces prol...

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Detalles Bibliográficos
Autores principales: Chand, Ashwini L., Wijayakumara, Dhilushi D., Knower, Kevin C., Herridge, Kerrie A., Howard, Tamara L., Lazarus, Kyren A., Clyne, Colin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281101/
https://www.ncbi.nlm.nih.gov/pubmed/22359603
http://dx.doi.org/10.1371/journal.pone.0031593

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