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Recognition of Anesthetic Barbiturates by a Protein Binding Site: A High Resolution Structural Analysis

Barbiturates potentiate GABA actions at the GABA(A) receptor and act as central nervous system depressants that can induce effects ranging from sedation to general anesthesia. No structural information has been available about how barbiturates are recognized by their protein targets. For this reason...

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Detalles Bibliográficos
Autores principales:	Oakley, Simon, Vedula, L. Sangeetha, Bu, Weiming, Meng, Qing Cheng, Xi, Jin, Liu, Renyu, Eckenhoff, Roderic G., Loll, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281113/ https://www.ncbi.nlm.nih.gov/pubmed/22359658 http://dx.doi.org/10.1371/journal.pone.0032070

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