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Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery

The present investigation concerns with the development of controlled release tablets of lamivudine using acetylated moth bean starch. The acetylated starch was synthesized with acetic anhydride in pyridine medium. The acetylated moth bean starch was tested for acute toxicity and drug–excipient comp...

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Detalles Bibliográficos
Autores principales: Singh, Akhilesh V., Nath, Lila K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281192/
https://www.ncbi.nlm.nih.gov/pubmed/22210486
http://dx.doi.org/10.1016/j.ijbiomac.2011.12.011
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author Singh, Akhilesh V.
Nath, Lila K.
author_facet Singh, Akhilesh V.
Nath, Lila K.
author_sort Singh, Akhilesh V.
collection PubMed
description The present investigation concerns with the development of controlled release tablets of lamivudine using acetylated moth bean starch. The acetylated starch was synthesized with acetic anhydride in pyridine medium. The acetylated moth bean starch was tested for acute toxicity and drug–excipient compatibility study. The formulations were evaluated for physical characteristics like hardness, friability, % drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi kinetic model and the release mechanism study proved that the formulation showed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T(max), C(max), AUC, V(d), T(1/2) and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir(®), which proved controlled release potential of acetylated moth bean starch.
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spelling pubmed-32811922012-03-01 Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery Singh, Akhilesh V. Nath, Lila K. Int J Biol Macromol Article The present investigation concerns with the development of controlled release tablets of lamivudine using acetylated moth bean starch. The acetylated starch was synthesized with acetic anhydride in pyridine medium. The acetylated moth bean starch was tested for acute toxicity and drug–excipient compatibility study. The formulations were evaluated for physical characteristics like hardness, friability, % drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi kinetic model and the release mechanism study proved that the formulation showed a combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T(max), C(max), AUC, V(d), T(1/2) and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir(®), which proved controlled release potential of acetylated moth bean starch. Elsevier 2012-03-01 /pmc/articles/PMC3281192/ /pubmed/22210486 http://dx.doi.org/10.1016/j.ijbiomac.2011.12.011 Text en © 2012 Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Article
Singh, Akhilesh V.
Nath, Lila K.
Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
title Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
title_full Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
title_fullStr Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
title_full_unstemmed Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
title_short Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
title_sort evaluation of acetylated moth bean starch as a carrier for controlled drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281192/
https://www.ncbi.nlm.nih.gov/pubmed/22210486
http://dx.doi.org/10.1016/j.ijbiomac.2011.12.011
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