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Using transcriptome sequencing to identify mechanisms of drug action and resistance
Determining mechanisms of drug action in human cells remains a major challenge. Here we describe an approach in which multiple drug resistant clones are isolated and transcriptome sequencing is used to find mutations in each clone. Further analysis of mutations common to more than one clone can iden...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281560/ https://www.ncbi.nlm.nih.gov/pubmed/22327403 http://dx.doi.org/10.1038/nchembio.779 |