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Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice

In obesity, rapidly expanding adipose tissue becomes hypoxic, precipitating inflammation, fibrosis, and insulin resistance. Compensatory angiogenesis may prevent these events. Mice lacking the intracellular glucocorticoid-amplifying enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1(−/−)) have...

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Detalles Bibliográficos
Autores principales:	Michailidou, Zoi, Turban, Sophie, Miller, Eileen, Zou, Xiantong, Schrader, Joerg, Ratcliffe, Peter J., Hadoke, Patrick W. F., Walker, Brian R., Iredale, John P., Morton, Nicholas M., Seckl, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281676/ https://www.ncbi.nlm.nih.gov/pubmed/22158867 http://dx.doi.org/10.1074/jbc.M111.259325

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