AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy

ADP-ribosylation factor 1 (Arf1) plays a major role in mediating vesicular transport. Brefeldin A (BFA), a known inhibitor of the Arf1-guanine nucleotide exchange factor (GEF) interaction, is highly cytotoxic. Therefore, interaction of Arf1 with ArfGEF is an attractive target for cancer treatment. H...

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Detalles Bibliográficos
Autores principales: Ohashi, Yoshimi, Iijima, Hiroshi, Yamaotsu, Noriyuki, Yamazaki, Kanami, Sato, Shigeo, Okamura, Mutsumi, Sugimoto, Kenji, Dan, Shingo, Hirono, Shuichi, Yamori, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281721/
https://www.ncbi.nlm.nih.gov/pubmed/22158626
http://dx.doi.org/10.1074/jbc.M111.316125

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