Cargando…

Enhancers and silencers: an integrated and simple model for their function

Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kolovos, Petros, Knoch, Tobias A, Grosveld, Frank G, Cook, Peter R, Papantonis, Argyris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281776/ https://www.ncbi.nlm.nih.gov/pubmed/22230046 http://dx.doi.org/10.1186/1756-8935-5-1

Ejemplares similares

TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning
por: Diermeier, Sarah, et al.
Publicado: (2014)

Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response
por: Kolovos, Petros, et al.
Publicado: (2016)

Forces driving the three‐dimensional folding of eukaryotic genomes
por: Rada‐Iglesias, Alvaro, et al.
Publicado: (2018)

Exploiting native forces to capture chromosome conformation in mammalian cell nuclei
por: Brant, Lilija, et al.
Publicado: (2016)

Chromatin Conformation in Development and Disease
por: Boltsis, Ilias, et al.
Publicado: (2021)

Genome architecture and the role of transcription
por: Papantonis, Argyris, et al.
Publicado: (2010)

Targeted Chromatin Capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements
por: Kolovos, Petros, et al.
Publicado: (2014)

Modes of phase separation affecting chromatin regulation
por: Palikyras, Spiros, et al.
Publicado: (2019)

The 4-D landscape of the inflammatory response
por: Papantonis, Argyris
Publicado: (2013)

Fine-structured multi-scaling long-range correlations in completely sequenced genomes—features, origin, and classification
por: Knoch, Tobias A., et al.
Publicado: (2009)

The dynamic emergence of GATA1 complexes identified in in vitro embryonic stem cell differentiation and in vivo mouse fetal liver
por: Yu, Xiao, et al.
Publicado: (2020)

Space exploration by the promoter of a long human gene during one transcription cycle
por: Larkin, Joshua D., et al.
Publicado: (2013)

Dissecting the nascent human transcriptome by analysing the RNA content of transcription factories
por: Caudron-Herger, Maïwen, et al.
Publicado: (2015)

The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes
por: Knoch, Tobias A., et al.
Publicado: (2016)

GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data
por: Estrada, Karol, et al.
Publicado: (2009)

Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions
por: Stadhouders, Ralph, et al.
Publicado: (2014)

The proteomes of transcription factories containing RNA polymerases I, II or III
por: Melnik, Svitlana, et al.
Publicado: (2011)

Cutting a Long Intron Short: Recursive Splicing and Its Implications
por: Georgomanolis, Theodore, et al.
Publicado: (2016)

Escape from senescence: revisiting cancer therapeutic strategies
por: Zampetidis, Christos P., et al.
Publicado: (2022)

Shaping epigenetic memory via genomic bookmarking
por: Michieletto, Davide, et al.
Publicado: (2018)

Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis
por: Giraud, Guillaume, et al.
Publicado: (2021)

GARLIC: a bioinformatic toolkit for aetiologically connecting diseases and cell type-specific regulatory maps
por: Nikolić, Miloš, et al.
Publicado: (2017)

Active RNA Polymerases: Mobile or Immobile Molecular Machines?
por: Papantonis, Argyris, et al.
Publicado: (2010)

CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells
por: Angelopoulou, Andriani, et al.
Publicado: (2022)

Targeted chromatin conformation analysis identifies novel distal neural enhancers of ZEB2 in pluripotent stem cell differentiation
por: Birkhoff, Judith C, et al.
Publicado: (2020)

Splicing of many human genes involves sites embedded within introns
por: Kelly, Steven, et al.
Publicado: (2015)

Dynamic behavior of GFP–CLIP-170 reveals fast protein turnover on microtubule plus ends
por: Dragestein, Katharina A., et al.
Publicado: (2008)

Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux
por: Palstra, Robert-Jan, et al.
Publicado: (2012)

Monitoring the Levels of Cellular NF-κB Activation States
por: Meier-Soelch, Johanna, et al.
Publicado: (2021)

Simple models for the integrated luminosity
por: Wenninger, J
Publicado: (2013)

Senescence‐associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells
por: Franzen, Julia, et al.
Publicado: (2016)

MIGS as a Simple and Efficient Method for Gene Silencing in Rice
por: Zheng, Xuelian, et al.
Publicado: (2018)

The Integral System
por: Petros, Peter
Publicado: (2011)

Botulinum toxin therapy: functional silencing of salivary disorders
por: Lovato, A., et al.
Publicado: (2017)

Conformational Dynamics of Ago-Mediated Silencing Processes
por: Willkomm, Sarah, et al.
Publicado: (2015)

A glimpse into the molecular mechanism of integral membrane proteins through hydrogen–deuterium exchange mass spectrometry
por: Martens, Chloe, et al.
Publicado: (2020)

Inter-Relationship between Testicular Dysgenesis and Leydig Cell Function in the Masculinization Programming Window in the Rat
por: van den Driesche, Sander, et al.
Publicado: (2012)

New Aspects of Gene-Silencing for the Treatment of Cardiovascular Diseases
por: Koenig, Olivia, et al.
Publicado: (2013)

Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype
por: Wallis, Ryan, et al.
Publicado: (2021)

RNAi revised - target mRNA-dependent enhancement of gene silencing
por: Dornseifer, Simon, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_doobqg9gbpt6mi5c7ipm0u4261