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Gender-specific regulation of response to thyroid hormone in aging

BACKGROUND: Similar to other systems, the endocrine system is affected by aging. Thyroid hormone, the action of which is affected by many factors, has been shown to be associated with longevity. The most useful marker for the assessment of thyroid hormone action is TSH level. Although age and gender...

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Autores principales: Suzuki, Satoru, Nishio, Shin-ichi, Takeda, Teiji, Komatsu, Mitsuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281778/
https://www.ncbi.nlm.nih.gov/pubmed/22280879
http://dx.doi.org/10.1186/1756-6614-5-1
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author Suzuki, Satoru
Nishio, Shin-ichi
Takeda, Teiji
Komatsu, Mitsuhisa
author_facet Suzuki, Satoru
Nishio, Shin-ichi
Takeda, Teiji
Komatsu, Mitsuhisa
author_sort Suzuki, Satoru
collection PubMed
description BACKGROUND: Similar to other systems, the endocrine system is affected by aging. Thyroid hormone, the action of which is affected by many factors, has been shown to be associated with longevity. The most useful marker for the assessment of thyroid hormone action is TSH level. Although age and gender are believed to modify the pituitary set point or response to free thyroid hormone concentration, the precise age- and gender-dependent responses to thyroid hormone have yet to be reported. METHODS: We analyzed the results of 3564 thyroid function tests obtained from patients who received medication at both out- and inpatient clinics of Shinshu University Hospital. Subjects were from among those with thyroid function test results in the normal or mildly abnormal range. Based on a log-linear relationship between the concentrations of FHs and TSH, we established the putative resistance index to assess the relation between serum FH and TSH levels. RESULTS: Free thyroid hormone and TSH concentration showed an inverse log-linear relation. In males, there was a negative relationship between the free T3 resistance index and age. In females, although there were no relationships between age and FHs, the indices were positively related to age. CONCLUSIONS: These findings indicated that there is a gender-specific response to thyroid hormone with aging. Although the TSH level is a useful marker for the assessment of peripheral thyroid hormone action, the values should be interpreted carefully, especially with regard to age- and gender-related differences.
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spelling pubmed-32817782012-02-22 Gender-specific regulation of response to thyroid hormone in aging Suzuki, Satoru Nishio, Shin-ichi Takeda, Teiji Komatsu, Mitsuhisa Thyroid Res Research BACKGROUND: Similar to other systems, the endocrine system is affected by aging. Thyroid hormone, the action of which is affected by many factors, has been shown to be associated with longevity. The most useful marker for the assessment of thyroid hormone action is TSH level. Although age and gender are believed to modify the pituitary set point or response to free thyroid hormone concentration, the precise age- and gender-dependent responses to thyroid hormone have yet to be reported. METHODS: We analyzed the results of 3564 thyroid function tests obtained from patients who received medication at both out- and inpatient clinics of Shinshu University Hospital. Subjects were from among those with thyroid function test results in the normal or mildly abnormal range. Based on a log-linear relationship between the concentrations of FHs and TSH, we established the putative resistance index to assess the relation between serum FH and TSH levels. RESULTS: Free thyroid hormone and TSH concentration showed an inverse log-linear relation. In males, there was a negative relationship between the free T3 resistance index and age. In females, although there were no relationships between age and FHs, the indices were positively related to age. CONCLUSIONS: These findings indicated that there is a gender-specific response to thyroid hormone with aging. Although the TSH level is a useful marker for the assessment of peripheral thyroid hormone action, the values should be interpreted carefully, especially with regard to age- and gender-related differences. BioMed Central 2012-01-26 /pmc/articles/PMC3281778/ /pubmed/22280879 http://dx.doi.org/10.1186/1756-6614-5-1 Text en Copyright ©2012 Suzuki et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Suzuki, Satoru
Nishio, Shin-ichi
Takeda, Teiji
Komatsu, Mitsuhisa
Gender-specific regulation of response to thyroid hormone in aging
title Gender-specific regulation of response to thyroid hormone in aging
title_full Gender-specific regulation of response to thyroid hormone in aging
title_fullStr Gender-specific regulation of response to thyroid hormone in aging
title_full_unstemmed Gender-specific regulation of response to thyroid hormone in aging
title_short Gender-specific regulation of response to thyroid hormone in aging
title_sort gender-specific regulation of response to thyroid hormone in aging
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281778/
https://www.ncbi.nlm.nih.gov/pubmed/22280879
http://dx.doi.org/10.1186/1756-6614-5-1
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AT komatsumitsuhisa genderspecificregulationofresponsetothyroidhormoneinaging