Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

BACKGROUND: Hypoxia-induced renal tubular cell epithelial–mesenchymal transition (EMT) is an important event leading to renal fibrosis. MicroRNAs (miRNAs) are small non-coding RNA molecules that bind to their mRNA targets, thereby leading to translational repression. The role of miRNA in hypoxia-ind...

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Detalles Bibliográficos
Autores principales: Du, Rui, Sun, Wenjuan, Xia, Lin, Zhao, Ali, Yu, Yan, Zhao, Lijuan, Wang, Hanmin, Huang, Chen, Sun, Shiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281867/
https://www.ncbi.nlm.nih.gov/pubmed/22363487
http://dx.doi.org/10.1371/journal.pone.0030771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281867/
https://www.ncbi.nlm.nih.gov/pubmed/22363487
http://dx.doi.org/10.1371/journal.pone.0030771

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