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Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein

Repeat proteins are increasingly attracting much attention as alternative scaffolds to immunoglobulin antibodies due to their unique structural features. Nonetheless, engineering interaction interface and understanding molecular basis for affinity maturation of repeat proteins still remain a challen...

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Detalles Bibliográficos
Autores principales:	Han, Jieun, Kim, Hyun Jung, Lee, Sang-Chul, Hong, Seungpyo, Park, Keunwan, Jeon, Young Ho, Kim, Dongsup, Cheong, Hae-Kap, Kim, Hak-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281905/ https://www.ncbi.nlm.nih.gov/pubmed/22363519 http://dx.doi.org/10.1371/journal.pone.0030929

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