Cargando…
Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index
BACKGROUND: Prolactin (PRL) secretion is quantifiable as mean, peak and nadir PRL concentrations, degree of irregularity (ApEn, approximate entropy) and spikiness (brief staccato-like fluctuations). HYPOTHESIS: Distinct PRL dynamics reflect relatively distinct (combinations of) subject variables, su...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281966/ https://www.ncbi.nlm.nih.gov/pubmed/22363612 http://dx.doi.org/10.1371/journal.pone.0031305 |
_version_ | 1782224026948599808 |
---|---|
author | Roelfsema, Ferdinand Pijl, Hanno Keenan, Daniel M. Veldhuis, Johannes D. |
author_facet | Roelfsema, Ferdinand Pijl, Hanno Keenan, Daniel M. Veldhuis, Johannes D. |
author_sort | Roelfsema, Ferdinand |
collection | PubMed |
description | BACKGROUND: Prolactin (PRL) secretion is quantifiable as mean, peak and nadir PRL concentrations, degree of irregularity (ApEn, approximate entropy) and spikiness (brief staccato-like fluctuations). HYPOTHESIS: Distinct PRL dynamics reflect relatively distinct (combinations of) subject variables, such as gender, age, and BMI. LOCATION: Clinical Research Unit. SUBJECTS: Seventy-four healthy adults aged 22–77 yr (41 women and 33 men), with BMI 18.3–39.4 kg/m(2). MEASURES: Immunofluorometric PRL assay of 10-min samples collected for 24 hours. RESULTS: Mean 24-h PRL concentration correlated jointly with gender (P<0.0001) and BMI (P = 0.01), but not with age (overall R(2) = 0.308, P<0.0001). Nadir PRL concentration correlated with gender only (P = 0.017) and peak PRL with gender (P<0.001) and negatively with age (P<0.003), overall R(2) = 0.325, P<0.0001. Forward-selection multivariate regression of PRL deconvolution results demonstrated that basal (nonpulsatile) PRL secretion tended to be associated with BMI (R(2) = 0.058, P = 0.03), pulsatile secretion with gender (R(2) = 0.152, P = 0.003), and total secretion with gender and BMI (R(2) = 0.204, P<0.0001). Pulse mass was associated with gender (P = 0.001) and with a negative tendency to age (P = 0.038). In male subjects older than 50 yr (but not in women) approximate entropy was increased (0.942±0.301 vs. 1.258±0.267, P = 0.007) compared with younger men, as well as spikiness (0.363±0.122 vs. 0463±2.12, P = 0.031). Cosinor analysis disclosed higher mesor and amplitude in females than in men, but the acrophase was gender-independent. The acrophase was determined by age and BMI (R(2) = 0.186, P = 0.001). CONCLUSION: In healthy adults, selective combinations of gender, age, and BMI specify distinct PRL dynamics, thus requiring balanced representation of these variables in comparative PRL studies. |
format | Online Article Text |
id | pubmed-3281966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32819662012-02-23 Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index Roelfsema, Ferdinand Pijl, Hanno Keenan, Daniel M. Veldhuis, Johannes D. PLoS One Research Article BACKGROUND: Prolactin (PRL) secretion is quantifiable as mean, peak and nadir PRL concentrations, degree of irregularity (ApEn, approximate entropy) and spikiness (brief staccato-like fluctuations). HYPOTHESIS: Distinct PRL dynamics reflect relatively distinct (combinations of) subject variables, such as gender, age, and BMI. LOCATION: Clinical Research Unit. SUBJECTS: Seventy-four healthy adults aged 22–77 yr (41 women and 33 men), with BMI 18.3–39.4 kg/m(2). MEASURES: Immunofluorometric PRL assay of 10-min samples collected for 24 hours. RESULTS: Mean 24-h PRL concentration correlated jointly with gender (P<0.0001) and BMI (P = 0.01), but not with age (overall R(2) = 0.308, P<0.0001). Nadir PRL concentration correlated with gender only (P = 0.017) and peak PRL with gender (P<0.001) and negatively with age (P<0.003), overall R(2) = 0.325, P<0.0001. Forward-selection multivariate regression of PRL deconvolution results demonstrated that basal (nonpulsatile) PRL secretion tended to be associated with BMI (R(2) = 0.058, P = 0.03), pulsatile secretion with gender (R(2) = 0.152, P = 0.003), and total secretion with gender and BMI (R(2) = 0.204, P<0.0001). Pulse mass was associated with gender (P = 0.001) and with a negative tendency to age (P = 0.038). In male subjects older than 50 yr (but not in women) approximate entropy was increased (0.942±0.301 vs. 1.258±0.267, P = 0.007) compared with younger men, as well as spikiness (0.363±0.122 vs. 0463±2.12, P = 0.031). Cosinor analysis disclosed higher mesor and amplitude in females than in men, but the acrophase was gender-independent. The acrophase was determined by age and BMI (R(2) = 0.186, P = 0.001). CONCLUSION: In healthy adults, selective combinations of gender, age, and BMI specify distinct PRL dynamics, thus requiring balanced representation of these variables in comparative PRL studies. Public Library of Science 2012-02-17 /pmc/articles/PMC3281966/ /pubmed/22363612 http://dx.doi.org/10.1371/journal.pone.0031305 Text en Roelfsema et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Roelfsema, Ferdinand Pijl, Hanno Keenan, Daniel M. Veldhuis, Johannes D. Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index |
title | Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index |
title_full | Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index |
title_fullStr | Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index |
title_full_unstemmed | Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index |
title_short | Prolactin Secretion in Healthy Adults Is Determined by Gender, Age and Body Mass Index |
title_sort | prolactin secretion in healthy adults is determined by gender, age and body mass index |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281966/ https://www.ncbi.nlm.nih.gov/pubmed/22363612 http://dx.doi.org/10.1371/journal.pone.0031305 |
work_keys_str_mv | AT roelfsemaferdinand prolactinsecretioninhealthyadultsisdeterminedbygenderageandbodymassindex AT pijlhanno prolactinsecretioninhealthyadultsisdeterminedbygenderageandbodymassindex AT keenandanielm prolactinsecretioninhealthyadultsisdeterminedbygenderageandbodymassindex AT veldhuisjohannesd prolactinsecretioninhealthyadultsisdeterminedbygenderageandbodymassindex |