The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood–brain barrier: Evidence for involvement of breast cancer resistance protein

Human African trypanosomiasis (HAT) is a parasitic disease affecting sub-Saharan Africa. The parasites are able to traverse the blood–brain barrier (BBB), which marks stage 2 (S2) of the disease. Delivery of anti-parasitic drugs across the BBB is key to treating S2 effectively and the difficulty in...

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Detalles Bibliográficos
Autores principales: Watson, Christopher P., Dogruel, Murat, Mihoreanu, Larisa, Begley, David J., Weksler, Babette B., Couraud, Pierre O., Romero, Ignacio A., Thomas, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2012
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281990/
https://www.ncbi.nlm.nih.gov/pubmed/22200378
http://dx.doi.org/10.1016/j.brainres.2011.11.053

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