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Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate

This study aimed to investigate the use of quinidine microdialysis to study potential changes in brain P-glycoprotein functionality after induction of status epilepticus (SE) by kainate. Rats were infused with 10 or 20 mg/kg quinidine over 30 min or 4 h. Plasma, brain extracellular fluid (brain ECF)...

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Detalles Bibliográficos
Autores principales:	Syvänen, Stina, Schenke, Maarten, van den Berg, Dirk-Jan, Voskuyl, Rob A., de Lange, Elizabeth C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281999/ https://www.ncbi.nlm.nih.gov/pubmed/22215264 http://dx.doi.org/10.1208/s12248-011-9318-1

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