Cargando…

Aclidinium inhibits human lung fibroblast to myofibroblast transition

BACKGROUND: Fibroblast to myofibroblast transition is believed to contribute to airway remodelling in lung diseases such as asthma and chronic obstructive pulmonary disease. This study examines the role of aclidinium, a new long-acting muscarinic antagonist, on human fibroblast to myofibroblast tran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Milara, Javier, Serrano, Adela, Peiró, Teresa, Gavaldà, Amadeu, Miralpeix, Montserrat, Morcillo, Esteban Jesús, Cortijo, Julio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Group 2011
Materias:	Chronic Obstructive Pulmonary Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282044/ https://www.ncbi.nlm.nih.gov/pubmed/21957094 http://dx.doi.org/10.1136/thoraxjnl-2011-200376

Ejemplares similares

Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials
por: McGarvey, Lorcan, et al.
Publicado: (2016)

Risk and temporal order of disease diagnosis of comorbidities in patients with COPD: a population health perspective
por: Tényi, Ákos, et al.
Publicado: (2018)

Increased expression of placenta growth factor in COPD
por: Cheng, S-L, et al.
Publicado: (2008)

Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease
por: Huang, Jeffrey T-J, et al.
Publicado: (2012)

Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD
por: Lewis, Amy, et al.
Publicado: (2011)

Quantification of dyspnoea using descriptors: development and initial testing of the Dyspnoea-12
por: Yorke, J, et al.
Publicado: (2010)

Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema
por: Mimae, Takahiro, et al.
Publicado: (2014)

Determinants and outcomes of physical activity in patients with COPD: a systematic review
por: Gimeno-Santos, Elena, et al.
Publicado: (2014)

Identifying the challenges and facilitators of implementing a COPD care bundle
por: Lennox, Laura, et al.
Publicado: (2014)

Attitudes and access to lung volume reduction surgery for COPD: a survey by the British Thoracic Society
por: McNulty, William, et al.
Publicado: (2014)

The impact of chronic obstructive pulmonary disease on intensive care unit admission and 30-day mortality in patients undergoing colorectal cancer surgery: a Danish population-based cohort study
por: Platon, Anna Maria, et al.
Publicado: (2014)

Microbial contamination of domiciliary nebulisers and clinical implications in chronic obstructive pulmonary disease
por: Jarvis, S, et al.
Publicado: (2014)

Lung volume reduction coil treatment for patients with severe emphysema: a European multicentre trial
por: Deslee, Gaëtan, et al.
Publicado: (2014)

Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD
por: Di Stefano, Antonino, et al.
Publicado: (2014)

Increased skeletal muscle-specific microRNA in the blood of patients with COPD
por: Donaldson, Anna, et al.
Publicado: (2013)

Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
por: van den Berge, Maarten, et al.
Publicado: (2014)

Measuring respiratory symptoms in clinical trials of COPD: reliability and validity of a daily diary
por: Leidy, N K, et al.
Publicado: (2014)

Targeted lung denervation for moderate to severe COPD: a pilot study
por: Slebos, Dirk-Jan, et al.
Publicado: (2015)

Efficacy and safety of once-daily QVA149 compared with the free combination of once-daily tiotropium plus twice-daily formoterol in patients with moderate-to-severe COPD (QUANTIFY): a randomised, non-inferiority study
por: Buhl, Roland, et al.
Publicado: (2015)

Driving performance in patients with chronic obstructive lung disease, interstitial lung disease and healthy controls: a crossover intervention study
por: Skovhus Prior, Thomas, et al.
Publicado: (2015)

Comparison of oxygen uptake during cycle ergometry with and without functional electrical stimulation in patients with COPD: protocol for a randomised, single-blind, placebo-controlled, cross-over trial
por: Medrinal, Clément, et al.
Publicado: (2016)

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study
por: McKeever, Tricia M, et al.
Publicado: (2016)

Randomised crossover trial of telemonitoring in chronic respiratory patients (TeleCRAFT trial)
por: Chatwin, M, et al.
Publicado: (2016)

Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study—a randomised controlled trial
por: Frith, Peter A, et al.
Publicado: (2015)

Neural respiratory drive predicts clinical deterioration and safe discharge in exacerbations of COPD
por: Suh, Eui-Sik, et al.
Publicado: (2015)

Validation of the DECAF score to predict hospital mortality in acute exacerbations of COPD
por: Echevarria, C, et al.
Publicado: (2016)

Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD
por: Pavord, Ian D, et al.
Publicado: (2016)

Productivity losses in chronic obstructive pulmonary disease: a population-based survey
por: Erdal, Marta, et al.
Publicado: (2014)

Necessity of amoxicillin clavulanic acid in addition to prednisolone in mild-to-moderate COPD exacerbations
por: Brusse-Keizer, Marjolein, et al.
Publicado: (2014)

Longitudinal change in quality of life following hospitalisation for acute exacerbations of COPD
por: Steer, John, et al.
Publicado: (2015)

An evaluation of factors associated with completion and benefit from pulmonary rehabilitation in COPD
por: Boutou, Afroditi K, et al.
Publicado: (2014)

Patients’ practices and experiences of using nebuliser therapy in the management of COPD at home
por: Alhaddad, B, et al.
Publicado: (2015)

Are clinical risk scores for COPD useful?
por: Quint, Jennifer K
Publicado: (2015)

Effects of different antibiotic classes on airway bacteria in stable COPD using culture and molecular techniques: a randomised controlled trial
por: Brill, Simon E, et al.
Publicado: (2015)

The effectiveness of a structured education pulmonary rehabilitation programme for improving the health status of people with moderate and severe chronic obstructive pulmonary disease in primary care: the PRINCE cluster randomised trial
por: Casey, Dympna, et al.
Publicado: (2013)

Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease
por: Inoue, Sumito, et al.
Publicado: (2017)

Effect of inhaled corticosteroids on blood eosinophil count in steroid-naïve patients with COPD
por: Kreindler, James L, et al.
Publicado: (2016)

Pulmonary artery perfusion versus no pulmonary perfusion during cardiopulmonary bypass in patients with COPD: a randomised clinical trial
por: Buggeskov, Katrine B, et al.
Publicado: (2016)

Physical frailty and pulmonary rehabilitation in COPD: a prospective cohort study
por: Maddocks, Matthew, et al.
Publicado: (2016)

Angiopoietin-like protein 4 and cardiovascular function in COPD
por: Waschki, B, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_j8d2rbd9sdhiatno9o3a4roeal