DNA-PK(CS) binding to p53 on the p21(WAF1/CIP1) promoter blocks transcription resulting in cell death

A key determinant of p53-mediated cell fate following various DNA damage modalities is p21(WAF1/CIP1) expression, with elevated p21 expression triggering cell cycle arrest and repressed p21 expression promoting apoptosis. We show that under pro-death DNA damage conditions, the DNA-dependent protein...

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Detalles Bibliográficos
Autores principales: Hill, Richard, Madureira, Patricia A., Waisman, David. M., Lee, Patrick W.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282069/
https://www.ncbi.nlm.nih.gov/pubmed/22190353

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