Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) axis regulates essential cellular functions including cell survival, proliferation, metabolism, migration, and angiogenesis. The PI3K pathway is activated in human cancers by mutation, amplification, and deletion of ge...

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Detalles Bibliográficos
Autores principales: Garrett, Joan T., Chakrabarty, Anindita, Arteaga, Carlos L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282088/
https://www.ncbi.nlm.nih.gov/pubmed/22248929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282088/
https://www.ncbi.nlm.nih.gov/pubmed/22248929

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