Is human cytomegalovirus a target in cancer therapy?

Human cytomegalovirus (HCMV) is a herpesvirus that is prevalent in the human population. HCMV has recently been implicated in different cancer forms where it may provide mechanisms for oncogenic transformation, oncomodulation and tumour cell immune evasion. Moreover, antiviral treatment against HCMV...

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Autores principales: Johnsen, John Inge, Baryawno, Ninib, Söderberg-Nauclér, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282090/
https://www.ncbi.nlm.nih.gov/pubmed/22246171
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author Johnsen, John Inge
Baryawno, Ninib
Söderberg-Nauclér, Cecilia
author_facet Johnsen, John Inge
Baryawno, Ninib
Söderberg-Nauclér, Cecilia
author_sort Johnsen, John Inge
collection PubMed
description Human cytomegalovirus (HCMV) is a herpesvirus that is prevalent in the human population. HCMV has recently been implicated in different cancer forms where it may provide mechanisms for oncogenic transformation, oncomodulation and tumour cell immune evasion. Moreover, antiviral treatment against HCMV has been shown to inhibit tumour growth in preclinical models. Here we describe the possible involvement of HCMV in cancer and discuss the potential molecular impact expression of HCMV proteins have on tumour cells and the surrounding tumour microenvironment.
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spelling pubmed-32820902012-02-22 Is human cytomegalovirus a target in cancer therapy? Johnsen, John Inge Baryawno, Ninib Söderberg-Nauclér, Cecilia Oncotarget Research Perspectives Human cytomegalovirus (HCMV) is a herpesvirus that is prevalent in the human population. HCMV has recently been implicated in different cancer forms where it may provide mechanisms for oncogenic transformation, oncomodulation and tumour cell immune evasion. Moreover, antiviral treatment against HCMV has been shown to inhibit tumour growth in preclinical models. Here we describe the possible involvement of HCMV in cancer and discuss the potential molecular impact expression of HCMV proteins have on tumour cells and the surrounding tumour microenvironment. Impact Journals LLC 2011-12-31 /pmc/articles/PMC3282090/ /pubmed/22246171 Text en Copyright: © 2011 Johnsen et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspectives
Johnsen, John Inge
Baryawno, Ninib
Söderberg-Nauclér, Cecilia
Is human cytomegalovirus a target in cancer therapy?
title Is human cytomegalovirus a target in cancer therapy?
title_full Is human cytomegalovirus a target in cancer therapy?
title_fullStr Is human cytomegalovirus a target in cancer therapy?
title_full_unstemmed Is human cytomegalovirus a target in cancer therapy?
title_short Is human cytomegalovirus a target in cancer therapy?
title_sort is human cytomegalovirus a target in cancer therapy?
topic Research Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282090/
https://www.ncbi.nlm.nih.gov/pubmed/22246171
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