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Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability. The kinesin-13 family is critical in the regulation of microtubule dynamics and the bes...

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Detalles Bibliográficos
Autores principales:	Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda, Louwen, Frank, Yuan, Juping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2011
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282097/ https://www.ncbi.nlm.nih.gov/pubmed/22249213

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