PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

Poly ADP-ribose polymerase (PARP) is a protein involved in single strand break repair. Recently, PARP inhibitors have shown considerable promise in the treatment of several cancers, both in monotherapy and in combination with cytotoxic agents. Synthetic lethal action of PARP inhibitors has been obse...

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Detalles Bibliográficos
Autores principales: van Vuurden, Dannis G., Hulleman, Esther, Meijer, Olga L.M., Wedekind, Laurine E., Kool, Marcel, Witt, Hendrik, Vandertop, Peter W. Peter, Würdinger, Thomas, Noske, David P., Kaspers, Gertjan J.L., Cloos, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282104/
https://www.ncbi.nlm.nih.gov/pubmed/22184287

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