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The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats

Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of...

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Autores principales: Park, Hyun-Jung, Shim, Hyun Soo, Kim, Kyung Soo, Shim, Insop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282220/
https://www.ncbi.nlm.nih.gov/pubmed/22359470
http://dx.doi.org/10.4196/kjpp.2011.15.6.333
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author Park, Hyun-Jung
Shim, Hyun Soo
Kim, Kyung Soo
Shim, Insop
author_facet Park, Hyun-Jung
Shim, Hyun Soo
Kim, Kyung Soo
Shim, Insop
author_sort Park, Hyun-Jung
collection PubMed
description Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the rats were administered BG (100 or 400 mgkg(-1), p.o.) daily for 2 weeks, followed by training and performance of the Morris water maze test. The rats with ischemic insults showed impaired learning and memory on the tasks. Treatment with BG produced improvement in the escape latency to find the platform. Further, the BG groups showed a reduced loss of cholinergic immunoreactivity and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in the hippocampus compared to that of the ISC group. These results demonstrated that BG has a protective effect against ischemia-induced neuronal and cognitive impairment. Our results suggest that BG might be useful for the treatment of vascular dementia.
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spelling pubmed-32822202012-02-22 The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats Park, Hyun-Jung Shim, Hyun Soo Kim, Kyung Soo Shim, Insop Korean J Physiol Pharmacol Original Article Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the rats were administered BG (100 or 400 mgkg(-1), p.o.) daily for 2 weeks, followed by training and performance of the Morris water maze test. The rats with ischemic insults showed impaired learning and memory on the tasks. Treatment with BG produced improvement in the escape latency to find the platform. Further, the BG groups showed a reduced loss of cholinergic immunoreactivity and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in the hippocampus compared to that of the ISC group. These results demonstrated that BG has a protective effect against ischemia-induced neuronal and cognitive impairment. Our results suggest that BG might be useful for the treatment of vascular dementia. The Korean Physiological Society and The Korean Society of Pharmacology 2011-12 2011-12-27 /pmc/articles/PMC3282220/ /pubmed/22359470 http://dx.doi.org/10.4196/kjpp.2011.15.6.333 Text en Copyright © 2011 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Hyun-Jung
Shim, Hyun Soo
Kim, Kyung Soo
Shim, Insop
The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
title The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
title_full The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
title_fullStr The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
title_full_unstemmed The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
title_short The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
title_sort protective effect of black ginseng against transient focal ischemia-induced neuronal damage in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282220/
https://www.ncbi.nlm.nih.gov/pubmed/22359470
http://dx.doi.org/10.4196/kjpp.2011.15.6.333
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