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The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282220/ https://www.ncbi.nlm.nih.gov/pubmed/22359470 http://dx.doi.org/10.4196/kjpp.2011.15.6.333 |
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author | Park, Hyun-Jung Shim, Hyun Soo Kim, Kyung Soo Shim, Insop |
author_facet | Park, Hyun-Jung Shim, Hyun Soo Kim, Kyung Soo Shim, Insop |
author_sort | Park, Hyun-Jung |
collection | PubMed |
description | Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the rats were administered BG (100 or 400 mgkg(-1), p.o.) daily for 2 weeks, followed by training and performance of the Morris water maze test. The rats with ischemic insults showed impaired learning and memory on the tasks. Treatment with BG produced improvement in the escape latency to find the platform. Further, the BG groups showed a reduced loss of cholinergic immunoreactivity and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in the hippocampus compared to that of the ISC group. These results demonstrated that BG has a protective effect against ischemia-induced neuronal and cognitive impairment. Our results suggest that BG might be useful for the treatment of vascular dementia. |
format | Online Article Text |
id | pubmed-3282220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Physiological Society and The Korean Society of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-32822202012-02-22 The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats Park, Hyun-Jung Shim, Hyun Soo Kim, Kyung Soo Shim, Insop Korean J Physiol Pharmacol Original Article Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the rats were administered BG (100 or 400 mgkg(-1), p.o.) daily for 2 weeks, followed by training and performance of the Morris water maze test. The rats with ischemic insults showed impaired learning and memory on the tasks. Treatment with BG produced improvement in the escape latency to find the platform. Further, the BG groups showed a reduced loss of cholinergic immunoreactivity and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in the hippocampus compared to that of the ISC group. These results demonstrated that BG has a protective effect against ischemia-induced neuronal and cognitive impairment. Our results suggest that BG might be useful for the treatment of vascular dementia. The Korean Physiological Society and The Korean Society of Pharmacology 2011-12 2011-12-27 /pmc/articles/PMC3282220/ /pubmed/22359470 http://dx.doi.org/10.4196/kjpp.2011.15.6.333 Text en Copyright © 2011 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Hyun-Jung Shim, Hyun Soo Kim, Kyung Soo Shim, Insop The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats |
title | The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats |
title_full | The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats |
title_fullStr | The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats |
title_full_unstemmed | The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats |
title_short | The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats |
title_sort | protective effect of black ginseng against transient focal ischemia-induced neuronal damage in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282220/ https://www.ncbi.nlm.nih.gov/pubmed/22359470 http://dx.doi.org/10.4196/kjpp.2011.15.6.333 |
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