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Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration
BACKGROUND. Valproic acid (VPA) apparent clearance (CL) estimated from total serum concentrations is analogous in elderly and non-elderly adult patients. As drug–protein binding decreases in old age, the aim of our study was to evaluate the confounding effect of the serum albumin concentration on th...
Autores principales: | Lampon, Natalia, Tutor, J. Carlos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282241/ https://www.ncbi.nlm.nih.gov/pubmed/22206465 http://dx.doi.org/10.3109/03009734.2011.640412 |
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