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Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler
Parasites can have detrimental effects on host fitness, and infection typically results in the stimulation of the immune system. While defending against infection, the immune system generates toxic oxidants; if these are not sufficiently counteracted by the antioxidant system, a state of oxidative s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282338/ https://www.ncbi.nlm.nih.gov/pubmed/22048952 http://dx.doi.org/10.1098/rspb.2011.1865 |
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author | van de Crommenacker, Janske Richardson, David S. Koltz, Amanda M. Hutchings, Kimberly Komdeur, Jan |
author_facet | van de Crommenacker, Janske Richardson, David S. Koltz, Amanda M. Hutchings, Kimberly Komdeur, Jan |
author_sort | van de Crommenacker, Janske |
collection | PubMed |
description | Parasites can have detrimental effects on host fitness, and infection typically results in the stimulation of the immune system. While defending against infection, the immune system generates toxic oxidants; if these are not sufficiently counteracted by the antioxidant system, a state of oxidative stress can occur. Here, we investigated the relationship between parasitic infection—using malarial infection as a model—and oxidative status in a natural population of the Seychelles warbler, while taking into account potentially interacting environmental covariates. We found that malaria is associated with increased susceptibility to oxidative stress, but this depends on the breeding stage: only during the energetically demanding provisioning stage did infected birds have higher oxidative stress susceptibility than non-infected birds. The imbalance in oxidative status was caused by a marked increase in oxidant levels observed only in infected birds during provisioning and by an overall reduction in antioxidant capacity observed in all birds across the breeding cycle. This finding implies that higher workload while dealing with an infection could aggravate oxidative repercussions. Malarial infection was not associated with body condition loss, suggesting that even when conditional effects are not directly visible, detrimental effects may still manifest themselves over the longer term through the oxidative consequences. |
format | Online Article Text |
id | pubmed-3282338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-32823382012-02-28 Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler van de Crommenacker, Janske Richardson, David S. Koltz, Amanda M. Hutchings, Kimberly Komdeur, Jan Proc Biol Sci Research Articles Parasites can have detrimental effects on host fitness, and infection typically results in the stimulation of the immune system. While defending against infection, the immune system generates toxic oxidants; if these are not sufficiently counteracted by the antioxidant system, a state of oxidative stress can occur. Here, we investigated the relationship between parasitic infection—using malarial infection as a model—and oxidative status in a natural population of the Seychelles warbler, while taking into account potentially interacting environmental covariates. We found that malaria is associated with increased susceptibility to oxidative stress, but this depends on the breeding stage: only during the energetically demanding provisioning stage did infected birds have higher oxidative stress susceptibility than non-infected birds. The imbalance in oxidative status was caused by a marked increase in oxidant levels observed only in infected birds during provisioning and by an overall reduction in antioxidant capacity observed in all birds across the breeding cycle. This finding implies that higher workload while dealing with an infection could aggravate oxidative repercussions. Malarial infection was not associated with body condition loss, suggesting that even when conditional effects are not directly visible, detrimental effects may still manifest themselves over the longer term through the oxidative consequences. The Royal Society 2012-04-22 2011-11-02 /pmc/articles/PMC3282338/ /pubmed/22048952 http://dx.doi.org/10.1098/rspb.2011.1865 Text en This journal is © 2011 The Royal Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles van de Crommenacker, Janske Richardson, David S. Koltz, Amanda M. Hutchings, Kimberly Komdeur, Jan Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler |
title | Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler |
title_full | Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler |
title_fullStr | Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler |
title_full_unstemmed | Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler |
title_short | Parasitic infection and oxidative status are associated and vary with breeding activity in the Seychelles warbler |
title_sort | parasitic infection and oxidative status are associated and vary with breeding activity in the seychelles warbler |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282338/ https://www.ncbi.nlm.nih.gov/pubmed/22048952 http://dx.doi.org/10.1098/rspb.2011.1865 |
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