Cargando…

Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor

Gastrointestinal stromal tumors (GISTs) are known to be poorly responsive to conventional chemotherapy and historically considered resistant to radiotherapy. In the past the mainstay of GIST treatment was surgery, but the introduction of tyrosine kinase inhibitors (TKIs) imatinib and sunitinib marke...

Descripción completa

Detalles Bibliográficos
Autores principales: Lolli, Cristian, Pantaleo, Maria Abbondanza, Nannini, Margherita, Saponara, Maristella, Pallotti, Maria Caterina, Scioscio, Valerio Di, Barbieri, Enza, Mandrioli, Anna, Biasco, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282454/
https://www.ncbi.nlm.nih.gov/pubmed/22355504
http://dx.doi.org/10.4081/rt.2011.e49
_version_ 1782224072332017664
author Lolli, Cristian
Pantaleo, Maria Abbondanza
Nannini, Margherita
Saponara, Maristella
Pallotti, Maria Caterina
Scioscio, Valerio Di
Barbieri, Enza
Mandrioli, Anna
Biasco, Guido
author_facet Lolli, Cristian
Pantaleo, Maria Abbondanza
Nannini, Margherita
Saponara, Maristella
Pallotti, Maria Caterina
Scioscio, Valerio Di
Barbieri, Enza
Mandrioli, Anna
Biasco, Guido
author_sort Lolli, Cristian
collection PubMed
description Gastrointestinal stromal tumors (GISTs) are known to be poorly responsive to conventional chemotherapy and historically considered resistant to radiotherapy. In the past the mainstay of GIST treatment was surgery, but the introduction of tyrosine kinase inhibitors (TKIs) imatinib and sunitinib marked the beginning of a new era in the treatment of GIST patients. To date, radiotherapy for GIST has not been administered in clinical practice except for limited palliative settings and there are no clear data on the administration of radiotherapy, alone or in combination with TKIs, with a purely cytoreductive intent. We describe the clinical case of a 48-year-old woman with metastatic GIST treated with external radiotherapy in a critical supraclavicular tumor localization progressively increasing in size with several symptoms and not responsive to systemic TKI therapies. We obtained an initial shrinkage of the mass and subsequent stabilization with an immediate and clear clinical benefit. Although the historical medical literature considered GISTs resistant to radiation therapy, our clinical case suggests this treatment may be appropriate in selected patients.
format Online
Article
Text
id pubmed-3282454
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher PAGEPress Publications
record_format MEDLINE/PubMed
spelling pubmed-32824542012-02-21 Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor Lolli, Cristian Pantaleo, Maria Abbondanza Nannini, Margherita Saponara, Maristella Pallotti, Maria Caterina Scioscio, Valerio Di Barbieri, Enza Mandrioli, Anna Biasco, Guido Rare Tumors Case Report Gastrointestinal stromal tumors (GISTs) are known to be poorly responsive to conventional chemotherapy and historically considered resistant to radiotherapy. In the past the mainstay of GIST treatment was surgery, but the introduction of tyrosine kinase inhibitors (TKIs) imatinib and sunitinib marked the beginning of a new era in the treatment of GIST patients. To date, radiotherapy for GIST has not been administered in clinical practice except for limited palliative settings and there are no clear data on the administration of radiotherapy, alone or in combination with TKIs, with a purely cytoreductive intent. We describe the clinical case of a 48-year-old woman with metastatic GIST treated with external radiotherapy in a critical supraclavicular tumor localization progressively increasing in size with several symptoms and not responsive to systemic TKI therapies. We obtained an initial shrinkage of the mass and subsequent stabilization with an immediate and clear clinical benefit. Although the historical medical literature considered GISTs resistant to radiation therapy, our clinical case suggests this treatment may be appropriate in selected patients. PAGEPress Publications 2011-10-26 /pmc/articles/PMC3282454/ /pubmed/22355504 http://dx.doi.org/10.4081/rt.2011.e49 Text en ©Copyright C. Lolli et al., 2011 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Case Report
Lolli, Cristian
Pantaleo, Maria Abbondanza
Nannini, Margherita
Saponara, Maristella
Pallotti, Maria Caterina
Scioscio, Valerio Di
Barbieri, Enza
Mandrioli, Anna
Biasco, Guido
Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
title Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
title_full Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
title_fullStr Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
title_full_unstemmed Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
title_short Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
title_sort successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282454/
https://www.ncbi.nlm.nih.gov/pubmed/22355504
http://dx.doi.org/10.4081/rt.2011.e49
work_keys_str_mv AT lollicristian successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT pantaleomariaabbondanza successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT nanninimargherita successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT saponaramaristella successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT pallottimariacaterina successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT sciosciovaleriodi successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT barbierienza successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT mandriolianna successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor
AT biascoguido successfulradiotherapyforlocalcontrolofprogressivelyincreasingmetastasisofgastrointestinalstromaltumor