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Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset
The NINDS trial demonstrated for the first time the effectiveness of intravenous thrombolysis in improving outcome after acute ischemic stroke. The absolute benefit of this intervention was 11–13% greater chance of being normal or near normal (MRS ≤ 1) at 3 months. However, if patients with severe s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282505/ https://www.ncbi.nlm.nih.gov/pubmed/22371764 http://dx.doi.org/10.5114/aoms.2010.14248 |
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author | Padma, Srivastava Majaz, Moonis |
author_facet | Padma, Srivastava Majaz, Moonis |
author_sort | Padma, Srivastava |
collection | PubMed |
description | The NINDS trial demonstrated for the first time the effectiveness of intravenous thrombolysis in improving outcome after acute ischemic stroke. The absolute benefit of this intervention was 11–13% greater chance of being normal or near normal (MRS ≤ 1) at 3 months. However, if patients with severe stroke were considered (NIHSS ≥ 20), the absolute benefit dropped to 5–6%, indicating that IV thrombolysis may not be as effective for large vessel occlusion. This observation was further supported by TCD studies that clearly demonstrated that large artery occlusions had a recanalization rate of 13–18% with IV rt-PA. Intra-arterial thrombolysis achieves recanalization rates of 60–70%. Since tissue viability is clearly important, it is time to stop defining rigid time windows and if there is a large penumbra (20–50%) and the occlusion is in a large artery, there exists a logic and a growing evidence to consider either bridge therapy or direct intra-arterial therapy. |
format | Online Article Text |
id | pubmed-3282505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-32825052012-02-27 Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset Padma, Srivastava Majaz, Moonis Arch Med Sci Review Paper The NINDS trial demonstrated for the first time the effectiveness of intravenous thrombolysis in improving outcome after acute ischemic stroke. The absolute benefit of this intervention was 11–13% greater chance of being normal or near normal (MRS ≤ 1) at 3 months. However, if patients with severe stroke were considered (NIHSS ≥ 20), the absolute benefit dropped to 5–6%, indicating that IV thrombolysis may not be as effective for large vessel occlusion. This observation was further supported by TCD studies that clearly demonstrated that large artery occlusions had a recanalization rate of 13–18% with IV rt-PA. Intra-arterial thrombolysis achieves recanalization rates of 60–70%. Since tissue viability is clearly important, it is time to stop defining rigid time windows and if there is a large penumbra (20–50%) and the occlusion is in a large artery, there exists a logic and a growing evidence to consider either bridge therapy or direct intra-arterial therapy. Termedia Publishing House 2010-06-30 2010-06-30 /pmc/articles/PMC3282505/ /pubmed/22371764 http://dx.doi.org/10.5114/aoms.2010.14248 Text en Copyright © 2010 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Paper Padma, Srivastava Majaz, Moonis Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset |
title | Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset |
title_full | Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset |
title_fullStr | Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset |
title_full_unstemmed | Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset |
title_short | Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset |
title_sort | intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282505/ https://www.ncbi.nlm.nih.gov/pubmed/22371764 http://dx.doi.org/10.5114/aoms.2010.14248 |
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