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Remote Ischemic Conditioning: From Bench to Bedside
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury (IRI). It describes an endogenous phenomenon in which the application of one or more brief cycles of non-lethal ischemia and reperfusion t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282534/ https://www.ncbi.nlm.nih.gov/pubmed/22363297 http://dx.doi.org/10.3389/fphys.2012.00027 |
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author | Lim, Shiang Yong Hausenloy, Derek John |
author_facet | Lim, Shiang Yong Hausenloy, Derek John |
author_sort | Lim, Shiang Yong |
collection | PubMed |
description | Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury (IRI). It describes an endogenous phenomenon in which the application of one or more brief cycles of non-lethal ischemia and reperfusion to an organ or tissue protects a remote organ or tissue from a sustained episode of lethal IRI. Although RIC protection was first demonstrated to protect the heart against acute myocardial infarction, its beneficial effects are also seen in other organs (lung, liver, kidney, intestine, brain) and tissues (skeletal muscle) subjected to acute IRI. The recent discovery that RIC can be induced non-invasively by simply inflating and deflating a standard blood pressure cuff placed on the upper arm or leg, has facilitated its translation into the clinical setting, where it has been reported to be beneficial in a variety of cardiac scenarios. In this review article we provide an overview of RIC, the potential underlying mechanisms, and its potential as a novel therapeutic strategy for protecting the heart and other organs from acute IRI. |
format | Online Article Text |
id | pubmed-3282534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32825342012-02-23 Remote Ischemic Conditioning: From Bench to Bedside Lim, Shiang Yong Hausenloy, Derek John Front Physiol Physiology Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury (IRI). It describes an endogenous phenomenon in which the application of one or more brief cycles of non-lethal ischemia and reperfusion to an organ or tissue protects a remote organ or tissue from a sustained episode of lethal IRI. Although RIC protection was first demonstrated to protect the heart against acute myocardial infarction, its beneficial effects are also seen in other organs (lung, liver, kidney, intestine, brain) and tissues (skeletal muscle) subjected to acute IRI. The recent discovery that RIC can be induced non-invasively by simply inflating and deflating a standard blood pressure cuff placed on the upper arm or leg, has facilitated its translation into the clinical setting, where it has been reported to be beneficial in a variety of cardiac scenarios. In this review article we provide an overview of RIC, the potential underlying mechanisms, and its potential as a novel therapeutic strategy for protecting the heart and other organs from acute IRI. Frontiers Research Foundation 2012-02-20 /pmc/articles/PMC3282534/ /pubmed/22363297 http://dx.doi.org/10.3389/fphys.2012.00027 Text en Copyright © 2012 Lim and Hausenloy. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Physiology Lim, Shiang Yong Hausenloy, Derek John Remote Ischemic Conditioning: From Bench to Bedside |
title | Remote Ischemic Conditioning: From Bench to Bedside |
title_full | Remote Ischemic Conditioning: From Bench to Bedside |
title_fullStr | Remote Ischemic Conditioning: From Bench to Bedside |
title_full_unstemmed | Remote Ischemic Conditioning: From Bench to Bedside |
title_short | Remote Ischemic Conditioning: From Bench to Bedside |
title_sort | remote ischemic conditioning: from bench to bedside |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282534/ https://www.ncbi.nlm.nih.gov/pubmed/22363297 http://dx.doi.org/10.3389/fphys.2012.00027 |
work_keys_str_mv | AT limshiangyong remoteischemicconditioningfrombenchtobedside AT hausenloyderekjohn remoteischemicconditioningfrombenchtobedside |