Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity

Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload – such as heart failure – and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses...

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Detalles Bibliográficos
Autores principales: Vink, Eva E., Blankestijn, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282535/
https://www.ncbi.nlm.nih.gov/pubmed/22363298
http://dx.doi.org/10.3389/fphys.2012.00029
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author Vink, Eva E.
Blankestijn, Peter J.
author_facet Vink, Eva E.
Blankestijn, Peter J.
author_sort Vink, Eva E.
collection PubMed
description Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload – such as heart failure – and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option.
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spelling pubmed-32825352012-02-23 Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity Vink, Eva E. Blankestijn, Peter J. Front Physiol Physiology Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload – such as heart failure – and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option. Frontiers Research Foundation 2012-02-20 /pmc/articles/PMC3282535/ /pubmed/22363298 http://dx.doi.org/10.3389/fphys.2012.00029 Text en Copyright © 2012 Vink and Blankestijn. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Physiology
Vink, Eva E.
Blankestijn, Peter J.
Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity
title Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity
title_full Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity
title_fullStr Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity
title_full_unstemmed Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity
title_short Evidence and Consequences of the Central Role of the Kidneys in the Pathophysiology of Sympathetic Hyperactivity
title_sort evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282535/
https://www.ncbi.nlm.nih.gov/pubmed/22363298
http://dx.doi.org/10.3389/fphys.2012.00029
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