Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips

BACKGROUND: Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth. RESULTS: Results showed...

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Detalles Bibliográficos
Autores principales: Na, Xiaofan, Hu, Yanfeng, Yue, Kun, Lu, Hongxia, Jia, Pengfei, Wang, Huahua, Wang, Xiaomin, Bi, Yurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282671/
https://www.ncbi.nlm.nih.gov/pubmed/22204558
http://dx.doi.org/10.1186/1471-2229-11-184
Descripción
Sumario:BACKGROUND: Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth. RESULTS: Results showed that the inhibition of NCS on cell division in Arabidopsis root tips and its effects on cell differentiation are concentration-dependent; at low concentrations (0.5 and 1.0 μM) NCS preferentially targets mitotic cell cycle specific/cyclin complexes, whereas at high concentration (5.0 μM) the NCS-stimulated accumulation of Kip-related proteins (KRP1 and RP2) affects the CDK complexes with a role at both G1/S and G2/M phases. CONCLUSIONS: Our findings suggest that NCS modulates the coordination between cell division and differentiation in Arabidopsis root tips and hence affects the postembryonic development of Arabidopsis seedlings.

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