Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips

BACKGROUND: Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth. RESULTS: Results showed...

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Autores principales: Na, Xiaofan, Hu, Yanfeng, Yue, Kun, Lu, Hongxia, Jia, Pengfei, Wang, Huahua, Wang, Xiaomin, Bi, Yurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282671/
https://www.ncbi.nlm.nih.gov/pubmed/22204558
http://dx.doi.org/10.1186/1471-2229-11-184
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author Na, Xiaofan
Hu, Yanfeng
Yue, Kun
Lu, Hongxia
Jia, Pengfei
Wang, Huahua
Wang, Xiaomin
Bi, Yurong
author_facet Na, Xiaofan
Hu, Yanfeng
Yue, Kun
Lu, Hongxia
Jia, Pengfei
Wang, Huahua
Wang, Xiaomin
Bi, Yurong
author_sort Na, Xiaofan
collection PubMed
description BACKGROUND: Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth. RESULTS: Results showed that the inhibition of NCS on cell division in Arabidopsis root tips and its effects on cell differentiation are concentration-dependent; at low concentrations (0.5 and 1.0 μM) NCS preferentially targets mitotic cell cycle specific/cyclin complexes, whereas at high concentration (5.0 μM) the NCS-stimulated accumulation of Kip-related proteins (KRP1 and RP2) affects the CDK complexes with a role at both G1/S and G2/M phases. CONCLUSIONS: Our findings suggest that NCS modulates the coordination between cell division and differentiation in Arabidopsis root tips and hence affects the postembryonic development of Arabidopsis seedlings.
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spelling pubmed-32826712012-02-21 Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips Na, Xiaofan Hu, Yanfeng Yue, Kun Lu, Hongxia Jia, Pengfei Wang, Huahua Wang, Xiaomin Bi, Yurong BMC Plant Biol Research Article BACKGROUND: Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth. RESULTS: Results showed that the inhibition of NCS on cell division in Arabidopsis root tips and its effects on cell differentiation are concentration-dependent; at low concentrations (0.5 and 1.0 μM) NCS preferentially targets mitotic cell cycle specific/cyclin complexes, whereas at high concentration (5.0 μM) the NCS-stimulated accumulation of Kip-related proteins (KRP1 and RP2) affects the CDK complexes with a role at both G1/S and G2/M phases. CONCLUSIONS: Our findings suggest that NCS modulates the coordination between cell division and differentiation in Arabidopsis root tips and hence affects the postembryonic development of Arabidopsis seedlings. BioMed Central 2011-12-28 /pmc/articles/PMC3282671/ /pubmed/22204558 http://dx.doi.org/10.1186/1471-2229-11-184 Text en Copyright ©2011 Na et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Na, Xiaofan
Hu, Yanfeng
Yue, Kun
Lu, Hongxia
Jia, Pengfei
Wang, Huahua
Wang, Xiaomin
Bi, Yurong
Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips
title Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips
title_full Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips
title_fullStr Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips
title_full_unstemmed Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips
title_short Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips
title_sort concentration-dependent effects of narciclasine on cell cycle progression in arabidopsis root tips
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282671/
https://www.ncbi.nlm.nih.gov/pubmed/22204558
http://dx.doi.org/10.1186/1471-2229-11-184
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