Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

This article outlines evidence that advanced glycation end product (AGE) inhibitors and breakers act primarily as chelators, inhibiting metal-catalyzed oxidation reactions that catalyze AGE formation. We then present evidence that chelation is the most likely mechanism by which ACE inhibitors, angio...

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Detalles Bibliográficos
Autores principales: Nagai, Ryoji, Murray, David B., Metz, Thomas O., Baynes, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Perspectives in Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282805/
https://www.ncbi.nlm.nih.gov/pubmed/22354928
http://dx.doi.org/10.2337/db11-1120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282805/
https://www.ncbi.nlm.nih.gov/pubmed/22354928
http://dx.doi.org/10.2337/db11-1120

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