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Free Fatty Acids Block Glucose-Induced β-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18

Pancreatic β-cell proliferation is infrequent in adult humans and is not increased in type 2 diabetes despite obesity and insulin resistance, suggesting the existence of inhibitory factors. Free fatty acids (FFAs) may influence proliferation. In order to test whether FFAs restrict β-cell proliferati...

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Detalles Bibliográficos
Autores principales:	Pascoe, Jordan, Hollern, Douglas, Stamateris, Rachel, Abbasi, Munira, Romano, Lia C., Zou, Baobo, O’Donnell, Christopher P., Garcia-Ocana, Adolfo, Alonso, Laura C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282818/ https://www.ncbi.nlm.nih.gov/pubmed/22338094 http://dx.doi.org/10.2337/db11-0991

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