Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function

Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secretion. Mice lacking β-cell ABCA1 have increased islet expression of ABCG1, another c...

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Detalles Bibliográficos
Autores principales: Kruit, Janine K., Wijesekara, Nadeeja, Westwell-Roper, Clara, Vanmierlo, Tim, de Haan, Willeke, Bhattacharjee, Alpana, Tang, Renmei, Wellington, Cheryl L., LütJohann, Dieter, Johnson, James D., Brunham, Liam R., Verchere, C. Bruce, Hayden, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282825/
https://www.ncbi.nlm.nih.gov/pubmed/22315310
http://dx.doi.org/10.2337/db11-1341

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