Cargando…

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and alterations of its function and/or expression are associated with several neurological conditions. By regulating intraneuronal chloride homeostasis, KCC2 strongly influences the efficacy and polarity of the ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chamma, Ingrid, Chevy, Quentin, Poncer, Jean Christophe, Lévi, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282916/ https://www.ncbi.nlm.nih.gov/pubmed/22363264 http://dx.doi.org/10.3389/fncel.2012.00005

Ejemplares similares

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity
por: Côme, Etienne, et al.
Publicado: (2019)

Current view on the functional regulation of the neuronal K(+)-Cl(−) cotransporter KCC2
por: Medina, Igor, et al.
Publicado: (2014)

The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington’s Disease and Its Comorbidities
por: Andrews, Katie, et al.
Publicado: (2020)

GABA(A) receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl(−)-sensitive WNK1 kinase
por: Heubl, Martin, et al.
Publicado: (2017)

Energetics of Excitatory and Inhibitory Neurotransmission in Aluminum Chloride Model of Alzheimer’s Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor
por: Saba, Kamal, et al.
Publicado: (2017)

The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2
por: Leonzino, Marianna, et al.
Publicado: (2016)

NAD+ Attenuates Bilirubin-Induced Hyperexcitation in the Ventral Cochlear Nucleus by Inhibiting Excitatory Neurotransmission and Neuronal Excitability
por: Liang, Min, et al.
Publicado: (2017)

Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice
por: Csillag, Veronika, et al.
Publicado: (2019)

Astrocytic GABA transporter activity modulates excitatory neurotransmission
por: Boddum, Kim, et al.
Publicado: (2016)

K(+)/Cl(−) cotransporter 2 (KCC2) and Na(+)/ [Formula: see text] cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation
por: Pethe, Abhishek, et al.
Publicado: (2023)

On the Phase Relationship between Excitatory and Inhibitory Neurons in Oscillation
por: Zou, Xiaolong, et al.
Publicado: (2016)

Learning excitatory-inhibitory neuronal assemblies in recurrent networks
por: Mackwood, Owen, et al.
Publicado: (2021)

An Excitatory/Inhibitory Switch From Asymmetric Sensory Neurons Defines Postsynaptic Tuning for a Rapid Response to NaCl in Caenorhabditis elegans
por: Kuramochi, Masahiro, et al.
Publicado: (2019)

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model
por: Giralt, Albert, et al.
Publicado: (2017)

Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis
por: Adragna, Norma C., et al.
Publicado: (2015)

The membrane trafficking and functionality of the K(+)-Cl(−) co-transporter KCC2 is regulated by TGF-β2
por: Roussa, Eleni, et al.
Publicado: (2016)

Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment
por: Szadai, Zoltán, et al.
Publicado: (2022)

BDNF-induced TrkB activation down-regulates the K(+)–Cl(−) cotransporter KCC2 and impairs neuronal Cl(−) extrusion
por: Rivera, Claudio, et al.
Publicado: (2002)

Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K(+)-Cl(−) Cotransporter KCC2
por: Tillman, Luke, et al.
Publicado: (2019)

Role of the K(+)-Cl(–) Cotransporter KCC2a Isoform in Mammalian Respiration at Birth
por: Dubois, Christophe J., et al.
Publicado: (2018)

Dynamics of Networks of Excitatory and Inhibitory Neurons in Response to Time-Dependent Inputs
por: Ledoux, Erwan, et al.
Publicado: (2011)

Interstitial cells of Cajal link excitatory and nitrergic inhibitory neurotransmission with slow-wave activity in the intestine
por: Klein, Sabine, et al.
Publicado: (2013)

Enhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius
por: Kukuia, Kennedy Kwami Edem, et al.
Publicado: (2016)

Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn
por: Lee, Kwan Yeop, et al.
Publicado: (2019)

Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks
por: Sadeh, Sadra, et al.
Publicado: (2021)

Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo
por: Gehr, Carolin, et al.
Publicado: (2023)

KCC2-dependent subcellular E(Cl) difference of ON-OFF retinal ganglion cells in larval zebrafish
por: Zhang, Rong-wei, et al.
Publicado: (2013)

Spontaneous and evoked neurotransmission are partially segregated at inhibitory synapses
por: Horvath, Patricia M, et al.
Publicado: (2020)

WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons
por: Lim, Wee Meng, et al.
Publicado: (2021)

Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats
por: Qian, Taizhe, et al.
Publicado: (2014)

Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility
por: Tworig, Joshua M, et al.
Publicado: (2021)

NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons
por: Pol, Erwan, et al.
Publicado: (2023)

Excitatory and Inhibitory Neurons in the Hippocampus Exhibit Molecularly Distinct Large Dense Core Vesicles
por: Ramírez-Franco, José J., et al.
Publicado: (2016)

Excitatory and inhibitory hippocampal neurons differ in their homeostatic adaptation to chronic M-channel modulation
por: Bar, Lior, et al.
Publicado: (2022)

Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
por: Kim, Mean-Hwan, et al.
Publicado: (2023)

A noninvasive optical approach for assessing chloride extrusion activity of the K–Cl cotransporter KCC2 in neuronal cells
por: Ludwig, Anastasia, et al.
Publicado: (2017)

Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
por: Zavalin, Kirill, et al.
Publicado: (2022)

On how correlations between excitatory and inhibitory synaptic inputs maximize the information rate of neuronal firing
por: Puzerey, Pavel A., et al.
Publicado: (2014)

CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons
por: Carriba, Paulina, et al.
Publicado: (2017)

Efficient Coding and Energy Efficiency Are Promoted by Balanced Excitatory and Inhibitory Synaptic Currents in Neuronal Network
por: Yu, Lianchun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9qq3i666e42onjgv5hecd777ig