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Current Management and Future Strategies of Gastric Cancer

The overall prognosis of gastric cancer has gradually improved over the past decades with growing awareness of potential carcinogens, surveillance programs and early diagnosis, as well as advances in surgical techniques and multimodality treatments. Nevertheless, the outcome of advanced stage diseas...

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Detalles Bibliográficos
Autores principales: Lee, Joong Ho, Kim, Kyung Min, Cheong, Jae-Ho, Noh, Sung Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282952/
https://www.ncbi.nlm.nih.gov/pubmed/22318810
http://dx.doi.org/10.3349/ymj.2012.53.2.248
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author Lee, Joong Ho
Kim, Kyung Min
Cheong, Jae-Ho
Noh, Sung Hoon
author_facet Lee, Joong Ho
Kim, Kyung Min
Cheong, Jae-Ho
Noh, Sung Hoon
author_sort Lee, Joong Ho
collection PubMed
description The overall prognosis of gastric cancer has gradually improved over the past decades with growing awareness of potential carcinogens, surveillance programs and early diagnosis, as well as advances in surgical techniques and multimodality treatments. Nevertheless, the outcome of advanced stage disease still remains poor with currently available treatments, and a worldwide consensus on the standard management thereof has not been established. To improve prognosis and quality of life in gastric cancer patients, both standardization and individualization of managements are imperative. Diagnostic tests and surgical procedures need to be further sophisticated and standardized based on more recent evidences from ongoing and future randomized controlled trials, while comprehensive management should be individualized to each patient. Future challenges lie with how to optimize personalized therapies by deciphering biological complexity of gastric cancer and incorporating molecular biomarkers in clinical practice to forecast prognosis and to guide targeted therapeutics in adjunct to current standards of care.
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spelling pubmed-32829522012-03-01 Current Management and Future Strategies of Gastric Cancer Lee, Joong Ho Kim, Kyung Min Cheong, Jae-Ho Noh, Sung Hoon Yonsei Med J Review Article The overall prognosis of gastric cancer has gradually improved over the past decades with growing awareness of potential carcinogens, surveillance programs and early diagnosis, as well as advances in surgical techniques and multimodality treatments. Nevertheless, the outcome of advanced stage disease still remains poor with currently available treatments, and a worldwide consensus on the standard management thereof has not been established. To improve prognosis and quality of life in gastric cancer patients, both standardization and individualization of managements are imperative. Diagnostic tests and surgical procedures need to be further sophisticated and standardized based on more recent evidences from ongoing and future randomized controlled trials, while comprehensive management should be individualized to each patient. Future challenges lie with how to optimize personalized therapies by deciphering biological complexity of gastric cancer and incorporating molecular biomarkers in clinical practice to forecast prognosis and to guide targeted therapeutics in adjunct to current standards of care. Yonsei University College of Medicine 2012-03-01 2012-01-30 /pmc/articles/PMC3282952/ /pubmed/22318810 http://dx.doi.org/10.3349/ymj.2012.53.2.248 Text en © Copyright: Yonsei University College of Medicine 2012 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Joong Ho
Kim, Kyung Min
Cheong, Jae-Ho
Noh, Sung Hoon
Current Management and Future Strategies of Gastric Cancer
title Current Management and Future Strategies of Gastric Cancer
title_full Current Management and Future Strategies of Gastric Cancer
title_fullStr Current Management and Future Strategies of Gastric Cancer
title_full_unstemmed Current Management and Future Strategies of Gastric Cancer
title_short Current Management and Future Strategies of Gastric Cancer
title_sort current management and future strategies of gastric cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282952/
https://www.ncbi.nlm.nih.gov/pubmed/22318810
http://dx.doi.org/10.3349/ymj.2012.53.2.248
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