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Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men?
PURPOSE: We aimed to determine whether 12 core-extended biopsies of the prostate could predict insignificant prostate cancer (IPCa) in Koreans reliably enough to recommend active surveillance. MATERIALS AND METHODS: Two hundred and ninety-seven patients who underwent radical prostatectomy after 12 c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282960/ https://www.ncbi.nlm.nih.gov/pubmed/22318824 http://dx.doi.org/10.3349/ymj.2012.53.2.358 |
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author | Yeom, Chan Dong Lee, Seung Hwan Park, Kyung Kgi Park, Sang Un Chung, Byung Ha |
author_facet | Yeom, Chan Dong Lee, Seung Hwan Park, Kyung Kgi Park, Sang Un Chung, Byung Ha |
author_sort | Yeom, Chan Dong |
collection | PubMed |
description | PURPOSE: We aimed to determine whether 12 core-extended biopsies of the prostate could predict insignificant prostate cancer (IPCa) in Koreans reliably enough to recommend active surveillance. MATERIALS AND METHODS: Two hundred and ninety-seven patients who underwent radical prostatectomy after 12 core-extended prostate biopsies were retrospectively reviewed. 38 cases (12.8%) were shown to be IPCa. RESULTS: The average age was 65.2 years, serum PSA was 5.49 ng/dL, and the PSA density was 0.11. The Gleason scores (GS) were 6 (3+3) in 31, 5 (3+2) in 4, and 4 (2+2) in 3. After radical prostatectomy, higher GS was given in 16 (42.1%), whereas lower GS was given in 1 case (2.6%), as compared with the GS obtained from biopsy. 11 (28.9%) had GS of 7 (3+4) and 5 (13.2%) had GS of 7 (4+3). 6 in GS 7 (4+3) and 1 in GS 7 (3+4) showed prostate capsule invasion and 1 in GS 7 (4+3) had seminal vesicle invasion. Prostate capsule invasion was observed in 1 with GS 6 (3+3). The rate of inaccuracy of the contemporary Epstein criteria was 42.1%. Only PSA density was a reliable indicator of clinically IPCa (odds ratio=1.384, 95% CI, 1.103 to 2.091). CONCLUSION: Diagnosis of IPCa from a prostate biopsy underestimated the true nature of prostate cancer in as many as 42.1% of Koreans. |
format | Online Article Text |
id | pubmed-3282960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-32829602012-03-01 Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men? Yeom, Chan Dong Lee, Seung Hwan Park, Kyung Kgi Park, Sang Un Chung, Byung Ha Yonsei Med J Original Article PURPOSE: We aimed to determine whether 12 core-extended biopsies of the prostate could predict insignificant prostate cancer (IPCa) in Koreans reliably enough to recommend active surveillance. MATERIALS AND METHODS: Two hundred and ninety-seven patients who underwent radical prostatectomy after 12 core-extended prostate biopsies were retrospectively reviewed. 38 cases (12.8%) were shown to be IPCa. RESULTS: The average age was 65.2 years, serum PSA was 5.49 ng/dL, and the PSA density was 0.11. The Gleason scores (GS) were 6 (3+3) in 31, 5 (3+2) in 4, and 4 (2+2) in 3. After radical prostatectomy, higher GS was given in 16 (42.1%), whereas lower GS was given in 1 case (2.6%), as compared with the GS obtained from biopsy. 11 (28.9%) had GS of 7 (3+4) and 5 (13.2%) had GS of 7 (4+3). 6 in GS 7 (4+3) and 1 in GS 7 (3+4) showed prostate capsule invasion and 1 in GS 7 (4+3) had seminal vesicle invasion. Prostate capsule invasion was observed in 1 with GS 6 (3+3). The rate of inaccuracy of the contemporary Epstein criteria was 42.1%. Only PSA density was a reliable indicator of clinically IPCa (odds ratio=1.384, 95% CI, 1.103 to 2.091). CONCLUSION: Diagnosis of IPCa from a prostate biopsy underestimated the true nature of prostate cancer in as many as 42.1% of Koreans. Yonsei University College of Medicine 2012-03-01 2012-01-30 /pmc/articles/PMC3282960/ /pubmed/22318824 http://dx.doi.org/10.3349/ymj.2012.53.2.358 Text en © Copyright: Yonsei University College of Medicine 2012 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yeom, Chan Dong Lee, Seung Hwan Park, Kyung Kgi Park, Sang Un Chung, Byung Ha Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men? |
title | Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men? |
title_full | Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men? |
title_fullStr | Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men? |
title_full_unstemmed | Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men? |
title_short | Are Clinically Insignificant Prostate Cancers Really Insignificant among Korean Men? |
title_sort | are clinically insignificant prostate cancers really insignificant among korean men? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282960/ https://www.ncbi.nlm.nih.gov/pubmed/22318824 http://dx.doi.org/10.3349/ymj.2012.53.2.358 |
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