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A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282982/ https://www.ncbi.nlm.nih.gov/pubmed/22355790 http://dx.doi.org/10.1038/srep00280 |
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author | Moriguchi, Hisashi Zhang, Yue Mihara, Makoto Sato, Chifumi |
author_facet | Moriguchi, Hisashi Zhang, Yue Mihara, Makoto Sato, Chifumi |
author_sort | Moriguchi, Hisashi |
collection | PubMed |
description | Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may be applicable to various human solid tumor cells that express aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors (RXRs). |
format | Online Article Text |
id | pubmed-3282982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-32829822012-02-21 A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals Moriguchi, Hisashi Zhang, Yue Mihara, Makoto Sato, Chifumi Sci Rep Article Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may be applicable to various human solid tumor cells that express aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors (RXRs). Nature Publishing Group 2012-02-21 /pmc/articles/PMC3282982/ /pubmed/22355790 http://dx.doi.org/10.1038/srep00280 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Moriguchi, Hisashi Zhang, Yue Mihara, Makoto Sato, Chifumi A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals |
title | A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals |
title_full | A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals |
title_fullStr | A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals |
title_full_unstemmed | A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals |
title_short | A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals |
title_sort | therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282982/ https://www.ncbi.nlm.nih.gov/pubmed/22355790 http://dx.doi.org/10.1038/srep00280 |
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