A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals

Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals....

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Autores principales: Moriguchi, Hisashi, Zhang, Yue, Mihara, Makoto, Sato, Chifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282982/
https://www.ncbi.nlm.nih.gov/pubmed/22355790
http://dx.doi.org/10.1038/srep00280
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author Moriguchi, Hisashi
Zhang, Yue
Mihara, Makoto
Sato, Chifumi
author_facet Moriguchi, Hisashi
Zhang, Yue
Mihara, Makoto
Sato, Chifumi
author_sort Moriguchi, Hisashi
collection PubMed
description Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may be applicable to various human solid tumor cells that express aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors (RXRs).
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spelling pubmed-32829822012-02-21 A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals Moriguchi, Hisashi Zhang, Yue Mihara, Makoto Sato, Chifumi Sci Rep Article Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may be applicable to various human solid tumor cells that express aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors (RXRs). Nature Publishing Group 2012-02-21 /pmc/articles/PMC3282982/ /pubmed/22355790 http://dx.doi.org/10.1038/srep00280 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Moriguchi, Hisashi
Zhang, Yue
Mihara, Makoto
Sato, Chifumi
A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
title A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
title_full A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
title_fullStr A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
title_full_unstemmed A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
title_short A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
title_sort therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282982/
https://www.ncbi.nlm.nih.gov/pubmed/22355790
http://dx.doi.org/10.1038/srep00280
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