An Anti-PCSK9 Antibody Reduces LDL-Cholesterol On Top Of A Statin And Suppresses Hepatocyte SREBP-Regulated Genes

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and antagonizes PCSK9 function in-vitro. In CETP/LDLR-hemi mice two successive doses of 1B20, a...

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Detalles Bibliográficos
Autores principales: Zhang, Liwen, McCabe, Timothy, Condra, Jon H., Ni, Yan G., Peterson, Laurence B., Wang, Weirong, Strack, Alison M., Wang, Fubao, Pandit, Shilpa, Hammond, Holly, Wood, Dana, Lewis, Dale, Rosa, Ray, Mendoza, Vivienne, Cumiskey, Anne Marie, Johns, Douglas G., Hansen, Barbara C., Shen, Xun, Geoghagen, Neil, Jensen, Kristian, Zhu, Lei, Wietecha, Karol, Wisniewski, Douglas, Huang, Lingyi, Zhao, Jing Zhang, Ernst, Robin, Hampton, Richard, Haytko, Peter, Ansbro, Frances, Chilewski, Shannon, Chin, Jayne, Mitnaul, Lyndon J., Pellacani, Andrea, Sparrow, Carl P., An, Zhiqiang, Strohl, William, Hubbard, Brian, Plump, Andrew S., Blom, Daniel, Sitlani, Ayesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282994/
https://www.ncbi.nlm.nih.gov/pubmed/22355267
http://dx.doi.org/10.7150/ijbs.3524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282994/
https://www.ncbi.nlm.nih.gov/pubmed/22355267
http://dx.doi.org/10.7150/ijbs.3524

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