Current Pharmacological Management in Juvenile Huntington’s Disease

Background: The clinical presentation of Juvenile Huntington’s Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management. Aim: To survey the current use of pharmacological treatments for JHD. Methods: Patients were identified through the HD Associat...

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Autores principales: Robertson, Lisa, Santini, Helen, O'Donovan, Kirsty L, Squitieri, Ferdinando, Barker, Roger A, Rakowicz, Maria, Landwehrmeyer, G. Bernhard, Quarrell, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283037/
https://www.ncbi.nlm.nih.gov/pubmed/22474619
http://dx.doi.org/10.1371/currents.RRN1304
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author Robertson, Lisa
Santini, Helen
O'Donovan, Kirsty L
Squitieri, Ferdinando
Barker, Roger A
Rakowicz, Maria
Landwehrmeyer, G. Bernhard
Quarrell, Oliver
author_facet Robertson, Lisa
Santini, Helen
O'Donovan, Kirsty L
Squitieri, Ferdinando
Barker, Roger A
Rakowicz, Maria
Landwehrmeyer, G. Bernhard
Quarrell, Oliver
author_sort Robertson, Lisa
collection PubMed
description Background: The clinical presentation of Juvenile Huntington’s Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management. Aim: To survey the current use of pharmacological treatments for JHD. Methods: Patients were identified through the HD Association, Hospital Doctors and the European Huntington’s Disease Network REGISTRY study. Results: The most commonly prescribed agents were anti-psychotics (24/45), anti-depressants (17/45) and anti-parkinsonian medications (15/45). 5 patients were taking more than 8 medications. Conclusions: The most commonly prescribed group of medication was the anti-psychotic. Many patients were on multiple therapies, highlighting the need to rationalise medications.
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spelling pubmed-32830372012-03-26 Current Pharmacological Management in Juvenile Huntington’s Disease Robertson, Lisa Santini, Helen O'Donovan, Kirsty L Squitieri, Ferdinando Barker, Roger A Rakowicz, Maria Landwehrmeyer, G. Bernhard Quarrell, Oliver PLoS Curr Huntington Disease Background: The clinical presentation of Juvenile Huntington’s Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management. Aim: To survey the current use of pharmacological treatments for JHD. Methods: Patients were identified through the HD Association, Hospital Doctors and the European Huntington’s Disease Network REGISTRY study. Results: The most commonly prescribed agents were anti-psychotics (24/45), anti-depressants (17/45) and anti-parkinsonian medications (15/45). 5 patients were taking more than 8 medications. Conclusions: The most commonly prescribed group of medication was the anti-psychotic. Many patients were on multiple therapies, highlighting the need to rationalise medications. Public Library of Science 2012-03-26 /pmc/articles/PMC3283037/ /pubmed/22474619 http://dx.doi.org/10.1371/currents.RRN1304 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Huntington Disease
Robertson, Lisa
Santini, Helen
O'Donovan, Kirsty L
Squitieri, Ferdinando
Barker, Roger A
Rakowicz, Maria
Landwehrmeyer, G. Bernhard
Quarrell, Oliver
Current Pharmacological Management in Juvenile Huntington’s Disease
title Current Pharmacological Management in Juvenile Huntington’s Disease
title_full Current Pharmacological Management in Juvenile Huntington’s Disease
title_fullStr Current Pharmacological Management in Juvenile Huntington’s Disease
title_full_unstemmed Current Pharmacological Management in Juvenile Huntington’s Disease
title_short Current Pharmacological Management in Juvenile Huntington’s Disease
title_sort current pharmacological management in juvenile huntington’s disease
topic Huntington Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283037/
https://www.ncbi.nlm.nih.gov/pubmed/22474619
http://dx.doi.org/10.1371/currents.RRN1304
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