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Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility
OBJECTIVE: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. METHODS: We genotyped the SNP...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society for Reproductive Medicine
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283048/ https://www.ncbi.nlm.nih.gov/pubmed/22384411 http://dx.doi.org/10.5653/cerm.2011.38.1.6 |
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author | Lee, Sun-Hee Lee, Suman |
author_facet | Lee, Sun-Hee Lee, Suman |
author_sort | Lee, Sun-Hee |
collection | PubMed |
description | OBJECTIVE: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. METHODS: We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping. RESULTS: The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155. CONCLUSION: The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility. |
format | Online Article Text |
id | pubmed-3283048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Society for Reproductive Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-32830482012-03-01 Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility Lee, Sun-Hee Lee, Suman Clin Exp Reprod Med Original Article OBJECTIVE: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. METHODS: We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping. RESULTS: The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155. CONCLUSION: The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility. The Korean Society for Reproductive Medicine 2011-03 2011-03-31 /pmc/articles/PMC3283048/ /pubmed/22384411 http://dx.doi.org/10.5653/cerm.2011.38.1.6 Text en Copyright © 2011. The Korean Society for Reproductive Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Sun-Hee Lee, Suman Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility |
title | Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility |
title_full | Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility |
title_fullStr | Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility |
title_full_unstemmed | Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility |
title_short | Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility |
title_sort | genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283048/ https://www.ncbi.nlm.nih.gov/pubmed/22384411 http://dx.doi.org/10.5653/cerm.2011.38.1.6 |
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