Casein phosphopeptides drastically increase the secretion of extracellular proteins in Aspergillus awamori. Proteomics studies reveal changes in the secretory pathway

BACKGROUND: The secretion of heterologous animal proteins in filamentous fungi is usually limited by bottlenecks in the vesicle-mediated secretory pathway. RESULTS: Using the secretion of bovine chymosin in Aspergillus awamori as a model, we found a drastic increase (40 to 80-fold) in cells grown wi...

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Detalles Bibliográficos
Autores principales: Kosalková, Katarina, García-Estrada, Carlos, Barreiro, Carlos, Flórez, Martha G, Jami, Mohammad S, Paniagua, Miguel A, Martín, Juan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283509/
https://www.ncbi.nlm.nih.gov/pubmed/22234238
http://dx.doi.org/10.1186/1475-2859-11-5

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