Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

BACKGROUND: The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard (125)I-insulin radiobinding assay (RBA) has low reproducibility between laboratories, long sample processing times and requires the use of ne...

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Detalles Bibliográficos
Autores principales: Lo, Bernice, Swafford, Austin DE, Shafer-Weaver, Kimberly A, Jerome, Lawrence F, Rakhlin, Luba, Mathern, Douglas R, Callahan, Conor A, Jiang, Ping, Davison, Lucy J, Stevens, Helen E, Lucas, Carrie L, White, Jill, von Borstel, Reid, Todd, John A, Lenardo, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283543/
https://www.ncbi.nlm.nih.gov/pubmed/22123298
http://dx.doi.org/10.1186/1479-5876-9-203

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