TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8(+) T Cell Survival and Homeostasis in Mice

The PI3K-Akt-mTOR pathway plays crucial roles in regulating both innate and adaptive immunity. However, the role of TSC1, a critical negative regulator of mTOR, in peripheral T cell homeostasis remains elusive. With T cell-specific Tsc1 conditional knockout (Tsc1 KO) mice, we found that peripheral n...

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Detalles Bibliográficos
Autores principales: Zhang, Lianjun, Zhang, Hongbing, Li, Lanlan, Xiao, Yi, Rao, Enyu, Miao, Zhuang, Chen, Hui, Sun, Lina, Li, Hongran, Liu, Guangwei, Zhao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283604/
https://www.ncbi.nlm.nih.gov/pubmed/22363451
http://dx.doi.org/10.1371/journal.pone.0030592

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