The BRG1 Chromatin Remodeler Protects Against Ovarian Cysts, Uterine Tumors, and Mammary Tumors in a Lineage-Specific Manner

The BRG1 catalytic subunit of SWI/SNF-related complexes is required for mammalian development as exemplified by the early embryonic lethality of Brg1 null homozygous mice. BRG1 is also a tumor suppressor and, in mice, 10% of heterozygous (Brg1(null/+)) females develop mammary tumors. We now demonstr...

Descripción completa

Detalles Bibliográficos
Autores principales: Serber, Daniel W., Rogala, Allison, Makarem, Maisam, Rosson, Gary B., Simin, Karl, Godfrey, Virginia, Van Dyke, Terry, Eaves, Connie J., Bultman, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283619/
https://www.ncbi.nlm.nih.gov/pubmed/22363625
http://dx.doi.org/10.1371/journal.pone.0031346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283619/
https://www.ncbi.nlm.nih.gov/pubmed/22363625
http://dx.doi.org/10.1371/journal.pone.0031346

Ejemplares similares