Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse

The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse. Sequencing the NS genome segment of mouse-adapted variants revealed 11 mutations in the NS1 gene and 4 in the overlapping NEP...

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Detalles Bibliográficos
Autores principales: Forbes, Nicole E., Ping, Jihui, Dankar, Samar K., Jia, Jian-Jun, Selman, Mohammed, Keleta, Liya, Zhou, Yan, Brown, Earl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283688/
https://www.ncbi.nlm.nih.gov/pubmed/22363747
http://dx.doi.org/10.1371/journal.pone.0031839

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