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Therapeutic Trial of Metformin and Bortezomib in a Mouse Model of Tuberous Sclerosis Complex (TSC)

Tuberous sclerosis complex (TSC) is a human genetic disorder in which loss of either TSC1 or TSC2 leads to development of hamartoma lesions, which can progress and be life-threatening or fatal. The TSC1/TSC2 protein complex regulates the state of activation of mTORC1. Tsc2(+/−) mice develop renal cy...

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Detalles Bibliográficos
Autores principales:	Auricchio, Neil, Malinowska, Izabela, Shaw, Reuben, Manning, Brendan D., Kwiatkowski, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283697/ https://www.ncbi.nlm.nih.gov/pubmed/22363765 http://dx.doi.org/10.1371/journal.pone.0031900

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