FKBP12 Activates the Cardiac Ryanodine Receptor Ca(2+)-Release Channel and Is Antagonised by FKBP12.6

Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca(2+)-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating. We have therefore investigated the effects of FKBP12.6 and anothe...

Descripción completa

Detalles Bibliográficos
Autores principales: Galfré, Elena, Pitt, Samantha J., Venturi, Elisa, Sitsapesan, Mano, Zaccai, Nathan R., Tsaneva-Atanasova, Krasimira, O'Neill, Stephen, Sitsapesan, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283708/
https://www.ncbi.nlm.nih.gov/pubmed/22363773
http://dx.doi.org/10.1371/journal.pone.0031956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283708/
https://www.ncbi.nlm.nih.gov/pubmed/22363773
http://dx.doi.org/10.1371/journal.pone.0031956

Ejemplares similares