Loss of Secreted Frizzled-Related Protein 4 Correlates with an Aggressive Phenotype and Predicts Poor Outcome in Ovarian Cancer Patients

BACKGROUND: Activation of the Wnt signaling pathway is implicated in aberrant cellular proliferation in various cancers. In 40% of endometrioid ovarian cancers, constitutive activation of the pathway is due to oncogenic mutations in β-catenin or other inactivating mutations in key negative regulator...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacob, Francis, Ukegjini, Kristjan, Nixdorf, Sheri, Ford, Caroline E., Olivier, Jake, Caduff, Rosmarie, Scurry, James P., Guertler, Rea, Hornung, Daniela, Mueller, Renato, Fink, Daniel A., Hacker, Neville F., Heinzelmann-Schwarz, Viola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283709/
https://www.ncbi.nlm.nih.gov/pubmed/22363760
http://dx.doi.org/10.1371/journal.pone.0031885

Ejemplares similares

Ejemplares similares